The study was undertaken to evaluate the anxiolytic effect of hydroalcoholic extract of Abutilon Indicum in mice. The Elevated Plus Maze model (EPM), Light and Dark Exploration model and Actophotometer were used to assess the anxiolytic activity of the hydroalcoholic extract of Abutilon indicum (200 and 400 mg/kg, p.o.) and Diazepam (2mg/kg, i.p.) in mice. Abutilon Indicum extract produced significant (p<0.05) reduction in spontaneous locomotor activity, indicating its CNS depressant nature. Administration of Abutilon Indicum extract produced significant (p<0.05) increase in light box entries and total time spent in the light box as compared to control group. In Elevated Plus maze model, administration of Abutilon Indicum extract (200 & 400 mg/kg) produced significant (p<0.05) increase in open arm entries and duration of time spent in open arm. It also increased percentage preference to open arm as compared to vehicle treated control group. Thus from the results we can conclude that hydro alcoholic extract of Abutilon Indicum possesses good anxiolytic activity.
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